Aug 2024~                  : Associate Professor, Institute of Biochemistry, National Chung Hsing University, Taichung City, Taiwan

Aug 2021~                  : Chief Director of Center. Center of EMI, National Chung Hsing University, Taichung City, Taiwan

Aug 2017~   Jul 2024 : Assistant Professor, Institute of Biochemistry, National Chung Hsing University, Taichung City, Taiwan

Jun 2012  ~ Jun 2017 : Post-doctoral researcher, Biochemistry and Biophysics Department, UNC_Chapel Hill, U.S.A.

Aug 2011 ~  May 2012: Post-doctoral researcher, Faculty of Life Sciences, School of Life Science, National Yang-Ming University, Taipei City, Taiwan

晝夜節律

核心時鐘_轉錄轉譯回饋迴圈

1. Yi-Ying Chiou, Michael G Kemp (2024, Jun) RNA polymerase tracking along damaged DNA: Impact on DNA repair and mutagenesis. PNAS 2024 Jun 4;121(23):e2408073121. (Comment)
2. Yi-Ying Chiou, Cing-Yun Lee, Hao-Wei Yang, Wei-Cheng Cheng, Kun-Da Ji (2024, Jan) Circadian modulation of glucose utilization via CRY1-mediated repression of Pdk1 expression. Journal of Biological Chemistry, 2024 Feb;300(2):105637
3. Yanchao Huang, Cem Azgari, Mengdie Yin, Yi-Ying Chiou, Laura A. Lindsey-Boltz, Aziz Sancar, Jinchuan Hu, Ogun Adebali (2022, Sep). Effects of replication domains on genome-wide UV-induced DNA damage and repair. PLOS genetics, 18(9): e1010426
4. YI-YING CHIOU, Tzu-Ying Li, Yanyan Yang, Aziz Sancar (2020, Dec). A sextuple knockout cell line system to study the differential roles of CRY, PER, and NR1D in the transcription translation feedback loop of the circadian clock. Frontiers in Neuroscience, 14;14:616802
5. Mei-Yin Liu , Wei-Kai Hua , Yi-Ying Chiou , Chi-Ju Chen , Chao-Ling Yao , YiTing Lai , Chao-Hsiung Lin , Wey-Jinq Lin (2019, Sep). Calcium-dependent methylation by PRMT1 promotes erythroid differentiation through the p38alpha MAPK pathway. FEBS LETTERS, 594, 301-316
6. Wang X, Jing C, Selby CP, Chiou YY, Yang Y, Wu W, Sancar A, Wang J. Comparative properties and functions of type 2 and type 4 pigeon cryptochromes. Cell Mol Life Sci. 2018 Sep 27. doi: 10.1007/s00018-018-2920-y
7. Yanyan Yang, Ogun Adebali, Gang Wub, Christopher P. Selbya, Yi-Ying Chiou, Naim Rashid, Jinchuan Hu, John B. Hogenesch, and Aziz Sancar. Cisplatin-DNA adduct repair of transcribed genes is controlled by two circadian programs in mouse tissues. PNAS 2018 115(21), E4777-E4785
8. Yi-Ying Chiou, Jinchuan Hu , Aziz Sancar , and Christopher P. Selby. RNA polymerase II is released from the DNA template during transcription-coupled repair in mammalian cells. Journal of Biological Chemistry 2018 293 (7), 2476-2486
9. Wentao Li, Jinchuan Hu, Ogun Adebali, Sheera Adara, Yanyan Yang, Yi-Ying Chiou, and Aziz Sancar. Human genome-wide repair map of DNA damage caused by the cigarette smoke carcinogen benzo[a]pyrene. PNAS 2017 114(26), 6752-6757
10. Ogun Adebali, Yi-Ying Chiou, Jinchuan Hu, Aziz Sancar, Christopher P. Selby. Genome-wide transcription-coupled repair in Escherichia coli is mediated by the Mfd protein. PNAS 2017 114(11), E2116-E2125
11. Yi-Ying Chiou*, Yanyan Yang*, Naim Rashid*, Rui Ye, Christopher P. Selby, Aziz Sancar (* equal contribution). Mammalian Period represses and de-represses transcription by displacing CLOCK-BMAL1 from promoters in a Cryptochrome-dependent manner. PNAS 2016 113 (41), E6072-E6079
12. JH Yang, YY Chiou, SL Fu, IY Shih, TH Weng, WJ Lin, CH Lin. Arginine methylation of hnRNPK negatively modulates apoptosis upon DNA damage through local regulation of phosphorylation. Nucleic acids research 2014 42 (15), 9908-9924
13. R Ye, CP Selby, YY Chiou, I Ozkan-Dagliyan, S Gaddameedhi, A Sancar. Dual modes of CLOCK: BMAL1 inhibition mediated by Cryptochrome and Period proteins in the mammalian circadian clock. Genes & development 2014 28 (18), 1989-1998
14. Y Annayev, S Adar, YY Chiou, JD Lieb, A Sancar, R Ye. Gene model 129 (Gm129) encodes a novel transcriptional repressor that modulates circadian gene expression. Journal of Biological Chemistry 2014 289 (8), 5013-5024
15. Aziz Sancar, Laura A Lindsey-Boltz, Shobhan Gaddameedhi, Christopher P Selby, Rui Ye, Yi-Ying Chiou, Michael G Kemp, Jinchuan Hu, Jin Hyup Lee, Nuri Ozturk. Circadian clock, cancer, and chemotherapy. Biochemistry 2014 54 (2), 110-123
16. Irem Ozkan-Dagliyan, Yi-Ying Chiou, Rui Ye, Bachar H Hassan, Nuri Ozturk, Aziz Sancar. Formation of Arabidopsis Cryptochrome 2 Photobodies in Mammalian Nuclei APPLICATION AS AN OPTOGENETIC DNA DAMAGE CHECKPOINT SWITCH. Journal of Biological Chemistry 2013 288 (32), 23244-23251
17. Chang YI, Lin SW, Chiou YY, Sung JS, Cheng LC, Lu YL, Sun KH, Chang K, Lin CH, Lin WJ.. Establishment of an ectopically expressed and functional PRMT1 for proteomic analysis of arginine-methylated proteins. Electrophoresis. 2010 Dec;31(23-24):3834-42
18. Lin YP, Hsu ME, Chiou YY, Hsu HY, Tsai HC, Peng YJ, Lu CY, Pan CY, Yu WC, Chen CH, Chi CW, Lin CH. Comparative proteomic analysis of rat aorta in a subtotal nephrectomy model. Proteomics. 2010 Jul;10(13):2429-43.
19. Chiou YY, Fu SL, Lin WJ, Lin CH. Proteomics analysis of in vitro protein methylation during Src-induced transformation. Electrophoresis. 2012 Electrophoresis 33 (3), 451-461
20. Chiou YY, Lin WJ, Fu SL, Lin CH. Direct mass-spectrometric identification of Arg296 and Arg299 as the methylation sites of hnRNP K protein for methyltransferase PRMT1. Protein J. 2007 Feb;26(2):87-9
21. Lee CS, Chien CT, Lin CH, Chiu YY, Yang YS. Protein changes between dormant and dormancy-broken seeds of Prunus campanulata Maxim. Proteomics. 2006 Jul;6(14):4147-54.