移至主內容

真核基因轉錄調控

蛋白質化學

邱奕穎 助理教授
國立陽明大學生物藥學所博士
生科大樓1213室
04-22840468#224~225
yychiou@nchu.edu.tw

Aug 2021~                  : Chief Director of Center. Center of EMI, National Chung Hsing University, Taichung City, Taiwan

Aug 2017~                  : Assistant Professor, Institute of Biochemistry, National Chung Hsing University, Taichung City, Taiwan

Jun 2012  ~ Jun 2017 : Post-doctoral researcher, Biochemistry and Biophysics Department, UNC_Chapel Hill, U.S.A.

Aug 2011 ~  May 2012: Post-doctoral researcher, Faculty of Life Sciences, School of Life Science, National Yang-Ming University, Taipei City, Taiwan

晝夜節律

核心時鐘_轉錄轉譯回饋迴圈

  1. Yi-Ying Chiou, Tzu-Ying Li, Yanyan Yang, Aziz Sancar (2020, Dec). A sextuple knockout cell line system to study the differential roles of CRY, PER, and NR1D in the transcription translation feedback loop of the circadian clock. Frontiers in Neuroscience, 14: 616802. MOST 106-2311-B-005-014. 第一作者、通訊作者.
  2. Mei-Yin Liu , Wei-Kai Hua , Yi-Ying Chiou , Chi-Ju Chen , Chao-Ling Yao , Yi-Ting Lai , Chao-Hsiung Lin , Wey-Jinq Lin (2019, Sep). Calcium-dependent methylation by PRMT1 promotes erythroid differentiation through the p38alpha MAPK pathway. FEBS LETTERS, 594, 301-316.
  3. Xuefeng Wang · Chengyu Jing · Christopher P. Selby · Yi‑Ying Chiou · Yanyan Yang · Wenjian Wu · Aziz Sancar · Jing Wang (2018, Sep). Comparative properties and functions of type 2 and type 4 pigeon cryptochromes. Cellular and Molecular Life Sciences, 75, 4629-4641.
  4. Yanyan Yang, Ogun Adebali, Gang Wu, Christopher P. Selby, Yi-Ying Chiou, Naim Rashid, Jinchuan Hu, John B. Hogenesch, and Aziz Sancar (2018, May). Cisplatin-DNA adduct repair of transcribed genes is controlled by two circadian programs in mouse tissues. Proceedings of the National Academy of Sciences , 115(21):E4777-E4785.
  5. Yi-Ying Chiou , Jinchuan Hu , Aziz Sancar , Christopher P Selby (2018, Feb). RNA polymerase II is released from the DNA template during transcription-coupled repair in mammalian cells. Journal of Biological Chemistry, 293(7)2476-2486. 第一作者.
  6. Wentao Li, Jinchuan Hu, Ogun Adebali, Sheera Adar, Yanyan Yang, Yi-Ying Chiou, Aziz Sancar (2017, Jun). Human genome-wide repair map of DNA damage caused by the cigarette smoke carcinogen benzo[a]pyrene. Proceedings of the National Academy of Sciences, 114(26):6752-6757. (SCI, 4/64, Multidisciplinary Science).
  7. Ogun Adebali Yi-Ying Chiou Jinchuan Hu, Aziz Sancar Christopher P. Selby (2017, Mar). Genome-wide transcription-coupled repair in Escherichia coli is mediated by the Mfd protein. Proceedings of the National Academy of Sciences, 114(11):E2116-E2125. (SCI, 4/64, Multidisciplinary Science).
  8. Yi-Ying Chiou, Yanyan Yang, Naim Rashid, Rui Ye, Christopher P. Selby, Aziz Sancar (2016, Oct). Mammalian Period represses and de-represses transcription by displacing CLOCK-BMAL1 from promoters in a Cryptochrome-dependent manner. Proceedings of the National Academy of Sciences, 113(41):E6072-E6079. (SCI, 4/64, Multidisciplinary Science). 第一作者.
  9. Aziz Sancar, Laura A Lindsey-Boltz, Shobhan Gaddameedhi, Christopher P Selby, Rui Ye, Yi-Ying Chiou, Michael G Kemp, Jinchuan Hu, Jin Hyup Lee, Nuri Ozturk (2015, Jan). Circadian clock, cancer, and chemotherapy. Biochemistry, 54(2):110-23. (SCI, 136/286, Biochemistry & Molecular Biology).
  10. Jen-Hao Yang, Yi-Ying Chiou, Shu-Ling Fu, I-Yun Shih, Tsai-Hsuan Weng, Wey-Jinq Lin, Chao-Hsiung Lin (2014, Sep). Arginine methylation of hnRNPK negatively modulates apoptosis upon DNA damage through local regulation of phosphorylation. Nucleic acids research, 42(15):9908-24. (SCI, 14/286, Biochemistry & Molecular Biology).
  11. Rui Ye, Cristopher P Selby, Yi-Ying Chiou, Irem Ozkan-Dagliyan, Shobhan Gaddameedhi, Aziz Sancar (2014, Sep). Dual modes of CLOCK: BMAL1 inhibition mediated by Cryptochrome and Period proteins in the mammalian circadian clock. Genes & development, 28(18):1989-98. (SCI, 17/189, Cell Biology).
  12. Yunus Annayev, Sheera Adar, Yi-Ying Chiou, Jason D Lieb, Aziz Sancar, Rui Ye (2014, Feb). Gene model 129 (Gm129) encodes a novel transcriptional repressor that modulates circadian gene expression. Journal of Biological Chemistry, 289(8):5013-24. (SCI, 74/286, Biochemistry & Molecular biology).
  13. Irem Ozkan-Dagliyan, Yi-Ying Chiou, Rui Ye, Bachar H Hassan, Nuri Ozturk, Aziz Sancar (2013, Aug). Formation of Arabidopsis Cryptochrome 2 Photobodies in Mammalian Nuclei application as an optogenetic DNA damage checkpoint switch. Journal of Biological Chemistry, 288(32):23244-51. (SCI, 74/286, Biochemistry & Molecular Biology).
  14. Yi‐Ying Chiou, Shu‐Ling Fu, Wey‐Jinq Lin, Chao‐Hsiung Lin (2012, Jan). Proteomics analysis of in vitro protein methylation during Src-induced transformation. Electrophoresis, 33(3):451-61. (SCI, 24/76, Chemistry, Analytical). 第一作者.  
  15. Yuan‐I Chang, Sheng‐Wei Lin, Yi‐Ying Chiou, Jung‐Sung Sung, Lee‐Chun Cheng, Yu‐Ling Lu, Kuang‐Hui Sun, Keejong Chang, Chao‐Hsiung Lin, Wey‐Jinq Lin (2010, Dec). Establishment of an ectopically expressed and functional PRMT1 for proteomic analysis of arginine-methylated proteins. Electrophoresis, 31(23-24):3834-42. (SCI, 24/76, Chemistry, Analytical).
  16. Yao‐Ping Lin, Meng‐Erh Hsu, Yi‐Ying Chiou, Hung‐Yi Hsu, Hiao‐Chien Tsai, Yu‐Ju Peng, Chi‐Yu Lu, Chien‐Yuan Pan, Wen‐Chung Yu, Chen‐Huan Chen, Chin‐Wen Chi, Chao‐Hsiung Lin (2010, Jul). Comparative proteomic analysis of rat aorta in a subtotal nephrectomy model. Proteomics, 10(13):2429-43. (SCI, 15/77, Biochemical Research Methods).     
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