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蛋白質轉譯調控研究

張功耀 教授
美國柏克萊加州大學博士
生命科學大樓1206室
04-22840468#218
kychang@dragon.nchu.edu.tw

國立中興大學 生物化學研究所 教授 2010~迄今

國立中興大學 生物化學研究所 所長 2019.08.01~2022.07.31

國立中興大學 生物化學研究所 兼任所長 2007~2010 

國立中興大學 生物化學研究所 副教授 2004~2010 

國立中興大學 生物化學研究所 助理教授 1999~2004

英國 MRC分子生物實驗室 訪問科學家 1997~1999 

美國柏克萊加州大學 化學系 博士後研究員 1995~1996 

美國柏克萊加州大學 化學系 博士 1990~1995 

台灣大學 生物化學 碩士 1988~1990 台灣大學 化學系 學士 1982~1986

 

 

 

 

 

  1. Hsu, H.T., Murata, A., Dohno, C., Nakatani, K., and Chang, K.Y. * (2022, May) “Premature translation termination mediated non-ER stress induced ATF6 activation by a ligand-dependent ribosomal frameshifting circuit”. Nucleic Acids Research, 50 (09), 5369-5383. (SCI). MOST 109-2311-B-005-010. 本人為通訊作者.

  2. Lydia M*. Castelli; Wan-Ping Huang; Ya-Hui Lin; Kung-Yao Chang*; Guillaume M. Hautbergue* (2021, Apr). Mechanisms of repeat-associated non-AUG translation in neu-rological microsatellite expansion disorders. Biochem Soc Trans, 49 (2): 775–792. MOST 108-2911-I-005-504. 本人為通訊作者.

  3. Wan-Ping Huang, Che-Pei Cho and Kung-Yao Chang * (2018, Dec). “mRNA mediated duplexes play dual roles in the regulation of bidirectional ribosomal frameshifting”. Internal Journal of Molecular Science, 19: 3867-3885. MOST 106-2313-B-005-056. 本人為通訊作者.

  4. Yu-Ting Chen, Kai-Chun Chang, Hao-Teng Hu, Yi-Lan Chen, You-Hsin Lin, Chiung-Fang Hsu, Cheng-Fu Chang, Kung-Yao Chang and Jin-Der Wen* (2017, Feb). Coordination among tertiary base pairs results in an efficient frameshift-stimulating RNA pseudoknot. Nucleic Acids Research, 45 (10), 6011-6022.

  5. Ya-Hui Lin and Kung-Yao Chang* (2016, Oct). Rational design of a synthetic mammalian riboswitch as a ligand-responsive -1 ribosomal frame-shifting stimulator. Nucleic Acids Research, 44 (18): 9005-9015. MOST 105-2311-B-005-004-MY3. 本人為通訊作者.

  6. Hao-Teng Hu, Che-Pei Cho, Ya-Hui Lin, and Kung-Yao Chang* (2016, Jan). A general strategy to inhibiting viral -1 frameshifting based on upstream attenuation duplex formation. Nucleic Acids Research, 44(1): 256-266. MOST 103-2627-M-005-001. 本人為通訊作者.

  7. Hsiu-Ting Hsu‡, Ya-Hui Lin‡, and Kung-Yao Chang* (2014, Dec). Synergetic regulation of translational reading-frame switch by ligand-responsive RNAs in mammalian cells. Nucleic Acids Research, 42(22), 14070-14082. 本人為通訊作者.

  8. Che-Pei Cho, Szu-Chieh Lin, Ming-Yuan Chou, Hsiu-Ting Hsu, and Kung-Yao Chang* (2013, Apr). Regulation of programmed ribosomal frameshifting by co-translational refolding RNA hairpins. PloS One, 8(4): e62283. 本人為通訊作者.

  9. Ming-Yuan Chou, Szu-Chieh Lin, and Kung-Yao Chang* (2010, Jun). Stimulation of -1 programmed ribosomal frameshifting by a metabolite-responsive RNA pseudoknot. RNA, 16, (6) 1636-1644. NSC 95-2311-B-005-013. 本人為通訊作者.

  10. Ming-Yuan Chou and Kung-Yao Chang* (2010, Mar). An intermolecular RNA triplex provides insight into structural determinants for the pseudoknot stimulator of -1 ribosomal frameshifting. Nucleic Acids Research, 38, (5) 1676-1685.. NSC 95-2311-B-005-013. 本人為通訊作者.

  11. Gang Chen, Kung-Yao Chang, Ming-Yuan Chou, Carlos Bustamantea, and Ignacio Tinoco, Jr.* (2009, Aug). Triplex structures in an RNA pseudoknot enhance mechanical stability and increase efficiency of -1 ribosomal frameshifting. PNAS, 106, (31) 12706-12711. NSC 95-2311-B-005-013.

  12. Mei-Chi Su, Chung-Te Chang, Chiu-Hui Chu, Ching-Hsiu Tsai, Kung-Yao Chang* (2005, Jul). An atypical RNA pseudoknot stimulator and an upstream attenuation signal for -1 ribosomal frameshifting of SARS coronavirus. Nucleic Acids Research, 33, (13) 4265-4275. NSC 92-2751-B-005-002-Y. 本人為通訊作者

   

 

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