移至主內容
張功耀 教授兼所長
美國柏克萊加州大學博士
生命科學大樓1206室
04-22840468#218
kychang@dragon.nchu.edu.tw

國立中興大學 生物化學研究所 所長 2019.08.01~

國立中興大學 生物化學研究所 教授 2010~迄今

國立中興大學 生物化學研究所 兼任所長 2007~2010 

國立中興大學 生物化學研究所 副教授 2004~2010 

國立中興大學 生物化學研究所 助理教授 1999~2004

英國 MRC分子生物實驗室 訪問科學家 1997~1999 

美國柏克萊加州大學 化學系 博士後研究員 1995~1996 

美國柏克萊加州大學 化學系 博士 1990~1995 

台灣大學 生物化學 碩士 1988~1990 台灣大學 化學系 學士 1982~1986

 

 

 

 

1.     Wan-Ping Huang, Che-Pei Cho and Kung-Yao Chang *.mRNA mediated duplexes play dual roles in the regulation of bidirectional ribosomal frameshifting”. Internal Journal of Molecular Science. 2018 Dec 4;19(12).

 

2.          Yu-Ting Chen, Kai-Chun Chang, Hao-Teng Hu, Yi-Lan Chen, You-Hsin Lin, Chiung-Fang Hsu, Cheng-Fu Chang, Kung-Yao Chang and Jin-Der Wen*. “Coordination among tertiary base pairs results in an efficient frameshift stimulating RNA pseudoknot.” Nucleic Acids Research, 45 (10): 6011-6022. (2017).

 

3.          Ya-Hui Lin and Kung-Yao Chang*. “Rational design of a synthetic mammalian riboswitch as a ligand-responsive -1 ribosomal frame-shifting stimulator.” Nucleic Acids Research, 44 (18): 9005-9015 (2016).

 

4.          Hao-Teng Hu, Che-Pei Cho, Ya-Hui Lin, and Kung-Yao Chang*. “A general strategy to inhibiting viral -1 frameshifting based on upstream attenuation duplex formation.” Nucleic Acids Research, 44(1): 256-266 (2016).

 

5.          Hsiu-Ting Hsu‡, Ya-Hui Lin‡, and Kung-Yao Chang*. “Synergetic regulation of translational reading-frame switch by ligand-responsive RNAs in mammalian cells.” Nucleic Acids Research, 42(22), 14070-14082 (2014).

 

6.          Che-Pei Cho, Szu-Chieh Lin, Ming-Yuan Chou, Hsiu-Ting Hsu, and Kung-Yao Chang*. “Regulation of programmed ribosomal frameshifting by cotranslational refolding RNA hairpins.” PloS One, 8(4): e62283 (2013).

 

7.          Ming-Yuan Chou, Szu-Chieh Lin, and Kung-Yao Chang* “Stimulation of -1 programmed ribosomal frameshifting by a metabolite-responsive RNA pseudoknot.” RNA. 16, 1236-1244 (2010).

 

8.          Ming-Yuan Chou and Kung-Yao Chang* “An intermolecular RNA triplex provides insight into structural determinants for the pseudoknot stimulator of -1 ribosomal frameshifting.” Nucleic Acids Res. 38, 1676-1685 (2010).

 

9.          Gang Chen, Kung-Yao Chang, Ming-Yuan Chou, Carlos Bustamantea, and Ignacio Tinoco, Jr. “Triplex structures in an RNA pseudoknot enhance mechanical stability and increase efficiency of –1 ribosomal frameshifting” Proc Natl Acad Sci USA. 106, 12706–12711 (2009).

 

10.      Su, M.C., Chu, C. H., Chang, C. T., Tsai, C. H., and Chang K. -Y.* “An atypical RNA pseudoknot of high -1 ribosomal frameshift efficiency and an upstream attenuation signal from SARS coronavirus genome.” Nucleic Acids Res. 33, 4265-4275 (2005).

 

 

   

 

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